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înseamnă că dacă opriţi tratamentul brusc sau lowerţi doza prea quick, puteţi prezenta simptome aleEt teoretisk volum som beskriver hvordan et legemiddel fordeler seg i vev og blodbane. Ved et lavt distribusjonsvolum fordeler legemiddelet seg i liten grad utenfor blodbanen.Administrarea concomitenta de inductori enzimatici, cum sunt barbitur
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